Quantitative Analysis of Uterine Action Potentials.

A fundamental problem in developing therapeutic interventions for uterine dysfunction is that the electrical profile of the myometrium, and how it changes in physiological, let alone pathophysiological, situations is unknown. Excitation-contraction coupling of the myometrium is a central component of healthy functioning of the uterus. Even though proper function of this smooth muscle is fundamental in women’s health, the electrical activity of the uterus is much understudied, and poorly understood. What is needed is a comprehensive quantitative electrophysiological approach involving experimentation and computer modeling, similar to that developed to understand excitation-contraction coupling in the heart.